Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis.
Identifieur interne : 001787 ( Main/Exploration ); précédent : 001786; suivant : 001788Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis.
Auteurs : William N. Whiteley [Royaume-Uni] ; Jonathan Emberson [Royaume-Uni] ; Kennedy R. Lees [Royaume-Uni] ; Lisa Blackwell [Royaume-Uni] ; Gregory Albers [États-Unis] ; Erich Bluhmki [Allemagne] ; Thomas Brott [États-Unis] ; Geoff Cohen [Royaume-Uni] ; Stephen Davis [Australie] ; Geoffrey Donnan [Australie] ; James Grotta [États-Unis] ; George Howard [États-Unis] ; Markku Kaste [Finlande] ; Masatoshi Koga [Japon] ; Rüdiger Von Kummer [Allemagne] ; Maarten G. Lansberg [États-Unis] ; Richard I. Lindley [Australie] ; Patrick Lyden [États-Unis] ; Jean Marc Olivot [France] ; Mark Parsons [Australie] ; Danilo Toni [Italie] ; Kazunori Toyoda [Japon] ; Nils Wahlgren [Suède] ; Joanna Wardlaw [Royaume-Uni] ; Gregory J. Del Zoppo [États-Unis] ; Peter Sandercock [Royaume-Uni] ; Werner Hacke [Allemagne] ; Colin Baigent [Royaume-Uni]Source :
- The Lancet. Neurology [ 1474-4465 ] ; 2016.
Descripteurs français
- KwdFr :
- Accident vasculaire cérébral (traitement médicamenteux), Accident vasculaire cérébral (étiologie), Activateur tissulaire du plasminogène (effets indésirables), Adulte, Adulte d'âge moyen, Bases de données factuelles (), Encéphalopathie ischémique (), Essais contrôlés randomisés comme sujet, Facteurs de l'âge, Facteurs temps, Femelle, Fibrinolytiques (effets indésirables), Humains, Hémorragie cérébrale (), Hémorragie cérébrale (épidémiologie), Modèles logistiques, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Évaluation de résultat (soins).
- MESH :
- effets indésirables : Activateur tissulaire du plasminogène, Fibrinolytiques.
- traitement médicamenteux : Accident vasculaire cérébral.
- épidémiologie : Hémorragie cérébrale.
- étiologie : Accident vasculaire cérébral.
- Adulte, Adulte d'âge moyen, Bases de données factuelles, Encéphalopathie ischémique, Essais contrôlés randomisés comme sujet, Facteurs de l'âge, Facteurs temps, Femelle, Humains, Hémorragie cérébrale, Modèles logistiques, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Évaluation de résultat (soins).
English descriptors
- KwdEn :
- Adult, Age Factors, Aged, Aged, 80 and over, Brain Ischemia (complications), Cerebral Hemorrhage (chemically induced), Cerebral Hemorrhage (epidemiology), Databases, Factual (statistics & numerical data), Female, Fibrinolytic Agents (adverse effects), Humans, Logistic Models, Male, Middle Aged, Outcome Assessment (Health Care), Randomized Controlled Trials as Topic, Stroke (drug therapy), Stroke (etiology), Time Factors, Tissue Plasminogen Activator (adverse effects).
- MESH :
- chemical , adverse effects : Fibrinolytic Agents, Tissue Plasminogen Activator.
- chemically induced : Cerebral Hemorrhage.
- complications : Brain Ischemia.
- drug therapy : Stroke.
- epidemiology : Cerebral Hemorrhage.
- etiology : Stroke.
- statistics & numerical data : Databases, Factual.
- Adult, Age Factors, Aged, Aged, 80 and over, Female, Humans, Logistic Models, Male, Middle Aged, Outcome Assessment (Health Care), Randomized Controlled Trials as Topic, Time Factors.
Abstract
Randomised trials have shown that alteplase improves the odds of a good outcome when delivered within 4·5 h of acute ischaemic stroke. However, alteplase also increases the risk of intracerebral haemorrhage; we aimed to determine the proportional and absolute effects of alteplase on the risks of intracerebral haemorrhage, mortality, and functional impairment in different types of patients.
DOI: 10.1016/S1474-4422(16)30076-X
PubMed: 27289487
Affiliations:
- Allemagne, Australie, Finlande, France, Italie, Japon, Royaume-Uni, Suède, États-Unis
- Alabama, Angleterre, Bade-Wurtemberg, Californie, District de Dresde, District de Karlsruhe, Floride, Latium, Nouvelle-Galles du Sud, Oxfordshire, Saxe (Land), Svealand, Texas, Uusimaa, Victoria (État), Washington (État), Écosse
- Dresde, Glasgow, Heidelberg, Helsinki, Melbourne, Oxford, Rome, Seattle, Stockholm, Sydney, Édimbourg
- Université d'Helsinki, Université d'Oxford, Université d'Édimbourg, Université de Glasgow, Université de Melbourne, Université de Sydney, Université de Washington
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Le document en format XML
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Electronic address: STT@ctsu.ox.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Trial Service Unit & Epidemiological Studies Unit, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27289487</idno><idno type="pmid">27289487</idno><idno type="doi">10.1016/S1474-4422(16)30076-X</idno><idno type="wicri:Area/PubMed/Corpus">001B31</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001B31</idno><idno type="wicri:Area/PubMed/Curation">001B07</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001B07</idno><idno type="wicri:Area/PubMed/Checkpoint">001B07</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001B07</idno><idno type="wicri:Area/Ncbi/Merge">003690</idno><idno type="wicri:Area/Ncbi/Curation">003690</idno><idno type="wicri:Area/Ncbi/Checkpoint">003690</idno><idno type="wicri:Area/Main/Merge">001782</idno><idno type="wicri:Area/Main/Curation">001787</idno><idno type="wicri:Area/Main/Exploration">001787</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis.</title><author><name sortKey="Whiteley, William N" sort="Whiteley, William N" uniqKey="Whiteley W" first="William N" last="Whiteley">William N. Whiteley</name><affiliation wicri:level="4"><nlm:affiliation>University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Emberson, Jonathan" sort="Emberson, Jonathan" uniqKey="Emberson J" first="Jonathan" last="Emberson">Jonathan Emberson</name><affiliation wicri:level="4"><nlm:affiliation>Clinical Trial Service Unit & Epidemiological Studies Unit, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Trial Service Unit & Epidemiological Studies Unit, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Lees, Kennedy R" sort="Lees, Kennedy R" uniqKey="Lees K" first="Kennedy R" last="Lees">Kennedy R. Lees</name><affiliation wicri:level="4"><nlm:affiliation>University of Glasgow, Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Blackwell, Lisa" sort="Blackwell, Lisa" uniqKey="Blackwell L" first="Lisa" last="Blackwell">Lisa Blackwell</name><affiliation wicri:level="4"><nlm:affiliation>Clinical Trial Service Unit & Epidemiological Studies Unit, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Trial Service Unit & Epidemiological Studies Unit, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Albers, Gregory" sort="Albers, Gregory" uniqKey="Albers G" first="Gregory" last="Albers">Gregory Albers</name><affiliation wicri:level="2"><nlm:affiliation>Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bluhmki, Erich" sort="Bluhmki, Erich" uniqKey="Bluhmki E" first="Erich" last="Bluhmki">Erich Bluhmki</name><affiliation wicri:level="1"><nlm:affiliation>Boehringer Ingelheim, Ingelheim, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Boehringer Ingelheim, Ingelheim</wicri:regionArea><wicri:noRegion>Ingelheim</wicri:noRegion><wicri:noRegion>Ingelheim</wicri:noRegion><wicri:noRegion>Ingelheim</wicri:noRegion></affiliation></author><author><name sortKey="Brott, Thomas" sort="Brott, Thomas" uniqKey="Brott T" first="Thomas" last="Brott">Thomas Brott</name><affiliation wicri:level="2"><nlm:affiliation>Mayo Clinic, Jacksonville, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Cohen, Geoff" sort="Cohen, Geoff" uniqKey="Cohen G" first="Geoff" last="Cohen">Geoff Cohen</name><affiliation wicri:level="4"><nlm:affiliation>University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Davis, Stephen" sort="Davis, Stephen" uniqKey="Davis S" first="Stephen" last="Davis">Stephen Davis</name><affiliation wicri:level="4"><nlm:affiliation>University of Melbourne, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Melbourne, Melbourne, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Donnan, Geoffrey" sort="Donnan, Geoffrey" uniqKey="Donnan G" first="Geoffrey" last="Donnan">Geoffrey Donnan</name><affiliation wicri:level="1"><nlm:affiliation>Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Florey Institute of Neuroscience and Mental Health, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Grotta, James" sort="Grotta, James" uniqKey="Grotta J" first="James" last="Grotta">James Grotta</name><affiliation wicri:level="2"><nlm:affiliation>Memorial Hermann Hospital, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Memorial Hermann Hospital, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Howard, George" sort="Howard, George" uniqKey="Howard G" first="George" last="Howard">George Howard</name><affiliation wicri:level="2"><nlm:affiliation>University of Alabama, Birmingham, AL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Alabama, Birmingham, AL</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Kaste, Markku" sort="Kaste, Markku" uniqKey="Kaste M" first="Markku" last="Kaste">Markku Kaste</name><affiliation wicri:level="4"><nlm:affiliation>Clinical Neurosciences, Neurology, University of Helsinki, Helsinki, Finland; Department of Neurology, Helsinki University Hospital, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Clinical Neurosciences, Neurology, University of Helsinki, Helsinki, Finland; Department of Neurology, Helsinki University Hospital, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Koga, Masatoshi" sort="Koga, Masatoshi" uniqKey="Koga M" first="Masatoshi" last="Koga">Masatoshi Koga</name><affiliation wicri:level="1"><nlm:affiliation>National Cerebral and Cardiovascular Centre, Suita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>National Cerebral and Cardiovascular Centre, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author><author><name sortKey="Von Kummer, Rudiger" sort="Von Kummer, Rudiger" uniqKey="Von Kummer R" first="Rüdiger" last="Von Kummer">Rüdiger Von Kummer</name><affiliation wicri:level="3"><nlm:affiliation>Technische Universität, Dresden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Technische Universität, Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Lansberg, Maarten G" sort="Lansberg, Maarten G" uniqKey="Lansberg M" first="Maarten G" last="Lansberg">Maarten G. Lansberg</name><affiliation wicri:level="2"><nlm:affiliation>Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lindley, Richard I" sort="Lindley, Richard I" uniqKey="Lindley R" first="Richard I" last="Lindley">Richard I. Lindley</name><affiliation wicri:level="4"><nlm:affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for Global Health, University of Sydney, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Lyden, Patrick" sort="Lyden, Patrick" uniqKey="Lyden P" first="Patrick" last="Lyden">Patrick Lyden</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Cedars-Sinai, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Cedars-Sinai, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Olivot, Jean Marc" sort="Olivot, Jean Marc" uniqKey="Olivot J" first="Jean Marc" last="Olivot">Jean Marc Olivot</name><affiliation wicri:level="1"><nlm:affiliation>Centre Hospitalier Universitaire de Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire de Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Parsons, Mark" sort="Parsons, Mark" uniqKey="Parsons M" first="Mark" last="Parsons">Mark Parsons</name><affiliation wicri:level="1"><nlm:affiliation>University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Newcastle, Newcastle, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Toni, Danilo" sort="Toni, Danilo" uniqKey="Toni D" first="Danilo" last="Toni">Danilo Toni</name><affiliation wicri:level="3"><nlm:affiliation>Sapienza University, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Sapienza University, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Toyoda, Kazunori" sort="Toyoda, Kazunori" uniqKey="Toyoda K" first="Kazunori" last="Toyoda">Kazunori Toyoda</name><affiliation wicri:level="1"><nlm:affiliation>National Cerebral and Cardiovascular Centre, Suita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>National Cerebral and Cardiovascular Centre, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author><author><name sortKey="Wahlgren, Nils" sort="Wahlgren, Nils" uniqKey="Wahlgren N" first="Nils" last="Wahlgren">Nils Wahlgren</name><affiliation wicri:level="3"><nlm:affiliation>Karolinska Institutet, Clinical Neuroscience, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Clinical Neuroscience, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Wardlaw, Joanna" sort="Wardlaw, Joanna" uniqKey="Wardlaw J" first="Joanna" last="Wardlaw">Joanna Wardlaw</name><affiliation wicri:level="4"><nlm:affiliation>University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Del Zoppo, Gregory J" sort="Del Zoppo, Gregory J" uniqKey="Del Zoppo G" first="Gregory J" last="Del Zoppo">Gregory J. Del Zoppo</name><affiliation wicri:level="4"><nlm:affiliation>University of Washington, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Sandercock, Peter" sort="Sandercock, Peter" uniqKey="Sandercock P" first="Peter" last="Sandercock">Peter Sandercock</name><affiliation wicri:level="4"><nlm:affiliation>University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Hacke, Werner" sort="Hacke, Werner" uniqKey="Hacke W" first="Werner" last="Hacke">Werner Hacke</name><affiliation wicri:level="3"><nlm:affiliation>University of Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Baigent, Colin" sort="Baigent, Colin" uniqKey="Baigent C" first="Colin" last="Baigent">Colin Baigent</name><affiliation wicri:level="4"><nlm:affiliation>Clinical Trial Service Unit & Epidemiological Studies Unit, University of Oxford, Oxford, UK. Electronic address: STT@ctsu.ox.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Trial Service Unit & Epidemiological Studies Unit, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author></analytic><series><title level="j">The Lancet. Neurology</title><idno type="eISSN">1474-4465</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Brain Ischemia (complications)</term><term>Cerebral Hemorrhage (chemically induced)</term><term>Cerebral Hemorrhage (epidemiology)</term><term>Databases, Factual (statistics & numerical data)</term><term>Female</term><term>Fibrinolytic Agents (adverse effects)</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Outcome Assessment (Health Care)</term><term>Randomized Controlled Trials as Topic</term><term>Stroke (drug therapy)</term><term>Stroke (etiology)</term><term>Time Factors</term><term>Tissue Plasminogen Activator (adverse effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Accident vasculaire cérébral (traitement médicamenteux)</term><term>Accident vasculaire cérébral (étiologie)</term><term>Activateur tissulaire du plasminogène (effets indésirables)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Bases de données factuelles ()</term><term>Encéphalopathie ischémique ()</term><term>Essais contrôlés randomisés comme sujet</term><term>Facteurs de l'âge</term><term>Facteurs temps</term><term>Femelle</term><term>Fibrinolytiques (effets indésirables)</term><term>Humains</term><term>Hémorragie cérébrale ()</term><term>Hémorragie cérébrale (épidémiologie)</term><term>Modèles logistiques</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Évaluation de résultat (soins)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Fibrinolytic Agents</term><term>Tissue Plasminogen Activator</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Cerebral Hemorrhage</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Brain Ischemia</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Activateur tissulaire du plasminogène</term><term>Fibrinolytiques</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cerebral Hemorrhage</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Databases, Factual</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Accident vasculaire cérébral</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Hémorragie cérébrale</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Accident vasculaire cérébral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Outcome Assessment (Health Care)</term><term>Randomized Controlled Trials as Topic</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Bases de données factuelles</term><term>Encéphalopathie ischémique</term><term>Essais contrôlés randomisés comme sujet</term><term>Facteurs de l'âge</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Hémorragie cérébrale</term><term>Modèles logistiques</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Évaluation de résultat (soins)</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Randomised trials have shown that alteplase improves the odds of a good outcome when delivered within 4·5 h of acute ischaemic stroke. However, alteplase also increases the risk of intracerebral haemorrhage; we aimed to determine the proportional and absolute effects of alteplase on the risks of intracerebral haemorrhage, mortality, and functional impairment in different types of patients.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Finlande</li><li>France</li><li>Italie</li><li>Japon</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Alabama</li><li>Angleterre</li><li>Bade-Wurtemberg</li><li>Californie</li><li>District de Dresde</li><li>District de Karlsruhe</li><li>Floride</li><li>Latium</li><li>Nouvelle-Galles du Sud</li><li>Oxfordshire</li><li>Saxe (Land)</li><li>Svealand</li><li>Texas</li><li>Uusimaa</li><li>Victoria (État)</li><li>Washington (État)</li><li>Écosse</li></region><settlement><li>Dresde</li><li>Glasgow</li><li>Heidelberg</li><li>Helsinki</li><li>Melbourne</li><li>Oxford</li><li>Rome</li><li>Seattle</li><li>Stockholm</li><li>Sydney</li><li>Édimbourg</li></settlement><orgName><li>Université d'Helsinki</li><li>Université d'Oxford</li><li>Université d'Édimbourg</li><li>Université de Glasgow</li><li>Université de Melbourne</li><li>Université de Sydney</li><li>Université de Washington</li></orgName></list><tree><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Whiteley, William N" sort="Whiteley, William N" uniqKey="Whiteley W" first="William N" last="Whiteley">William N. Whiteley</name></region><name sortKey="Baigent, Colin" sort="Baigent, Colin" uniqKey="Baigent C" first="Colin" last="Baigent">Colin Baigent</name><name sortKey="Blackwell, Lisa" sort="Blackwell, Lisa" uniqKey="Blackwell L" first="Lisa" last="Blackwell">Lisa Blackwell</name><name sortKey="Cohen, Geoff" sort="Cohen, Geoff" uniqKey="Cohen G" first="Geoff" last="Cohen">Geoff Cohen</name><name sortKey="Emberson, Jonathan" sort="Emberson, Jonathan" uniqKey="Emberson J" first="Jonathan" last="Emberson">Jonathan Emberson</name><name sortKey="Lees, Kennedy R" sort="Lees, Kennedy R" uniqKey="Lees K" first="Kennedy R" last="Lees">Kennedy R. Lees</name><name sortKey="Sandercock, Peter" sort="Sandercock, Peter" uniqKey="Sandercock P" first="Peter" last="Sandercock">Peter Sandercock</name><name sortKey="Wardlaw, Joanna" sort="Wardlaw, Joanna" uniqKey="Wardlaw J" first="Joanna" last="Wardlaw">Joanna Wardlaw</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Albers, Gregory" sort="Albers, Gregory" uniqKey="Albers G" first="Gregory" last="Albers">Gregory Albers</name></region><name sortKey="Brott, Thomas" sort="Brott, Thomas" uniqKey="Brott T" first="Thomas" last="Brott">Thomas Brott</name><name sortKey="Del Zoppo, Gregory J" sort="Del Zoppo, Gregory J" uniqKey="Del Zoppo G" first="Gregory J" last="Del Zoppo">Gregory J. Del Zoppo</name><name sortKey="Grotta, James" sort="Grotta, James" uniqKey="Grotta J" first="James" last="Grotta">James Grotta</name><name sortKey="Howard, George" sort="Howard, George" uniqKey="Howard G" first="George" last="Howard">George Howard</name><name sortKey="Lansberg, Maarten G" sort="Lansberg, Maarten G" uniqKey="Lansberg M" first="Maarten G" last="Lansberg">Maarten G. Lansberg</name><name sortKey="Lyden, Patrick" sort="Lyden, Patrick" uniqKey="Lyden P" first="Patrick" last="Lyden">Patrick Lyden</name></country><country name="Allemagne"><noRegion><name sortKey="Bluhmki, Erich" sort="Bluhmki, Erich" uniqKey="Bluhmki E" first="Erich" last="Bluhmki">Erich Bluhmki</name></noRegion><name sortKey="Hacke, Werner" sort="Hacke, Werner" uniqKey="Hacke W" first="Werner" last="Hacke">Werner Hacke</name><name sortKey="Von Kummer, Rudiger" sort="Von Kummer, Rudiger" uniqKey="Von Kummer R" first="Rüdiger" last="Von Kummer">Rüdiger Von Kummer</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Davis, Stephen" sort="Davis, Stephen" uniqKey="Davis S" first="Stephen" last="Davis">Stephen Davis</name></region><name sortKey="Donnan, Geoffrey" sort="Donnan, Geoffrey" uniqKey="Donnan G" first="Geoffrey" last="Donnan">Geoffrey Donnan</name><name sortKey="Lindley, Richard I" sort="Lindley, Richard I" uniqKey="Lindley R" first="Richard I" last="Lindley">Richard I. Lindley</name><name sortKey="Parsons, Mark" sort="Parsons, Mark" uniqKey="Parsons M" first="Mark" last="Parsons">Mark Parsons</name></country><country name="Finlande"><region name="Uusimaa"><name sortKey="Kaste, Markku" sort="Kaste, Markku" uniqKey="Kaste M" first="Markku" last="Kaste">Markku Kaste</name></region></country><country name="Japon"><noRegion><name sortKey="Koga, Masatoshi" sort="Koga, Masatoshi" uniqKey="Koga M" first="Masatoshi" last="Koga">Masatoshi Koga</name></noRegion><name sortKey="Toyoda, Kazunori" sort="Toyoda, Kazunori" uniqKey="Toyoda K" first="Kazunori" last="Toyoda">Kazunori Toyoda</name></country><country name="France"><noRegion><name sortKey="Olivot, Jean Marc" sort="Olivot, Jean Marc" uniqKey="Olivot J" first="Jean Marc" last="Olivot">Jean Marc Olivot</name></noRegion></country><country name="Italie"><region name="Latium"><name sortKey="Toni, Danilo" sort="Toni, Danilo" uniqKey="Toni D" first="Danilo" last="Toni">Danilo Toni</name></region></country><country name="Suède"><region name="Svealand"><name sortKey="Wahlgren, Nils" sort="Wahlgren, Nils" uniqKey="Wahlgren N" first="Nils" last="Wahlgren">Nils Wahlgren</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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